In this collaboration with the University of Alabama at Birmingham, PET radiotracers targeting CD8 and CD4 were used in a murine model of breast cancer to establish a correlation between the changes in CD4+ and CD8+ T-cells, and long-term anti-tumor response to immune checkpoint inhibitors (ICB) in immunologically “cold” tumors. Through advanced PET imaging techniques, this study shows the visualization of distribution activity of CD4+ and CD8+ T-cells during ICB treatment.
