Los Angeles: October 31st, 2011 — ImaginAb, Inc. is pleased to announce that it has been awarded a total of $2.3 million in funding from the National Cancer Institute’s (NCI) Small Business Innovation Research (SBIR) program to help further develop diagnostic imaging agents for Positron Emission Tomography (PET). Over the past 20 years, PET has evolved into a powerful and highly valued tool for the clinical management of cancer but many important areas of oncology still lack effective diagnostic and staging tools – particularly pancreatic and prostate cancer. It is estimated that over 70,000 people in the United States alone die of pancreatic and prostate cancer annually. ImaginAb’s Head of Pre-Clinical Development, Dr. David Ho, will be the Principal Investigator in close collaboration with Dr. David Colcher at the City of Hope (Duarte, CA). ImaginAb will use this funding over the next two years to further accelerate its clinical program.

“The NCI SBIR program has become a very important source of financing for early-stage oncology companies, particularly considering the lack of risk capital available and changes in the early stage venture capital landscape over the past few years,” noted Dr. Christian Behrenbruch, CEO of ImaginAb. “These funds from the NCI will be invested alongside ImaginAb resources to help drive our prostate and pancreatic oncology program ahead even more aggressively. The NCI has been a true partner in helping move our technology forward and have provided not only funding, but also access to clinical expertise and relationships with potential investors and pharma.”

“For a company the size of ImaginAb, the NCI SBIR program is an invaluable source of funds that will greatly help with moving our lead products closer to commercialization,” commented Jenny Keppler, ImaginAb’s President and Chief Operating Officer. “The highly competitive and peer-reviewed nature of NCI funding ensures that the most promising research is given an opportunity for development and commercialization.”

About ImaginAb, Inc.

Founded in 2007 by UCLA Faculty (Drs. Robert Reiter, Anna Wu and Christian Behrenbruch), ImaginAb, Inc. is a biotechnology company specializing in the development of engineered antibody fragments for diagnostic imaging and novel therapeutic applications. The company has a significant pipeline of clinical products in development oriented towards unmet needs in cancer and immunology. ImaginAb is also developing a range of pre-clinical (animal imaging) reagents for use with microPET, microSPECT and optical imaging systems, and partners on a selective basis with biopharmaceutical companies with an interest in developing companion imaging agents for therapeutic antibody products. For more information about ImaginAb, visit www.imaginab.com.

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ImaginAb:

Los Angeles & Singapore, 6th September, 2011 — ImaginAb, Inc. is pleased to announce the establishment of a wholly owned Singapore-based subsidiary, ImaginAb Molecular Imaging Pte Ltd (IMI). IMI is the first step in the company’s international expansion and marks a significant increase in research capability for the organization. IMI will be established to provide GLP pre-clinical molecular imaging services to both the US parent company and select biopharma partnerships, including optical imaging and positron emission tomography (PET) services.

Christian P. Behrenbruch, Ph.D, ImaginAb’s CEO, commented, “Singapore has tremendous resources and facilities of interest to ImaginAb. We already have a close dialog with several A*Star Research Institutes (RIs) and a formalized collaboration with Sir David Lane’s lab at the Institute of Molecular Biology (IMB).” The establishment of IMI will strengthen the possibility of further collaborations with A*Star, university labs and several global pharmaceutical companies who have established translational medicine units in Singapore.

“Establishing a significant research footprint in Singapore has been a straightforward process, greatly facilitated by the ease of working with A*Star, EDB and other government stakeholders who are committed to bringing highly innovative US companies to a growing and dynamic biotech cluster,” commented Dr. Behrenbruch. “We are impressed with the quality of industry-accessible core resources and the international talent base in Singapore. We also expect ImaginAb’s footprint in Singapore will also enable the company to better service a rapidly growing client base in Korea, Japan and China.”

About ImaginAb

Founded in 2007 by UCLA Faculty (Drs. Robert Reiter, Anna Wu and Christian Behrenbruch), ImaginAb, Inc. is a biotechnology company specializing in the development of engineered antibody fragments for diagnostic imaging and novel therapeutic applications. The company has a significant pipeline of clinical products in development oriented towards unmet needs in cancer and immunology. ImaginAb is also developing a range of pre-clinical (animal imaging) reagents for use with microPET, microSPECT and optical imaging systems, and partners on a selective basis with biopharmaceutical companies with an interest in developing companion imaging agents for therapeutic antibody products. For more information about ImaginAb, visit www.imaginab.com.

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ImaginAb:

San Antonio Tx, June 7th — ImaginAb, Inc. is pleased to announce the availability of custom radiolabeling services for proteins, peptides and other macromolecules as of the 1st of July 2011. This is part of the company’s ongoing initiative to broaden the range of product and service offerings to the biopharma and research community and is synergistic with existing activities in custom antibody fragment engineering.

“Over the past 18 months we have grown our core antibody engineering program to over a dozen ‘companion diagnostic’ programs with pharmaceutical companies in addition to our own internal pipeline” commented Jenny Keppler, President and COO of ImaginAb. “In response to very high demand for our radiochemistry and, in particular our antibody labeling expertise, we have decided to make this capability a standard service offering as part of our recent LA facility expansion”

Protein/peptide labeling services will initially focus on F-18, Cu-64, I-124. Please contact sales@imaginab.com for further information and pricing.

About ImaginAb

Founded in 2007 by UCLA Faculty (Drs. Robert Reiter, Anna Wu and Christian Behrenbruch), ImaginAb, Inc. is a biotechnology company specializing in the development of engineered antibody fragments for diagnostic imaging and novel therapeutic applications. The company has a significant pipeline of clinical products in development oriented towards unmet needs in cancer and immunology. ImaginAb is also developing a range of pre-clinical (animal imaging) reagents for use with microPET, microSPECT and optical imaging systems, and partners on a selective basis with biopharmaceutical companies with an interest in developing companion imaging agents for therapeutic antibody products. For more information about ImaginAb, visit www.imaginab.com.

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ImaginAb:

*the technologies described in this press release are available for pre-clinical / non-human use only.

PRESS RELEASE

Oxford, UK – 6 June 2011: Oxford BioMedica plc (“Oxford BioMedica” or “the Company”) (LSE: OXB), a leading gene therapy company, today announces that it has signed a research collaboration agreement with ImaginAb, Inc. (“ImaginAb”), a biotechnology company specialising in the development of engineered antibody fragments for diagnostic imaging and novel therapeutic applications, to engineer an in vivo diagnostic imaging agent using an antibody targeting the Company’s proprietary 5T4 tumour antigen. Following proof-of-concept, the agreement includes an option for ImaginAb to negotiate an exclusive license for commercialisation of an in vivo 5T4-based imaging diagnostic. On that basis, Oxford BioMedica could receive proceeds of up to US$4 million in initiation and development milestone payments, in addition to royalties on product sales, subject to the achievement of certain programme objectives.

ImaginAb plans to develop an in vivo diagnostic imaging agent for positron emission tomography (PET), a nuclear medicine imaging technique that produces a three-dimensional image of functional processes in the body, which will initially be applied to ovarian cancer imaging.

John Dawson, Chief Executive Officer of Oxford BioMedica, said: “Having recently broadened our partnership with Pfizer for the ‘in vitro’ diagnostic use of antibodies targeting our 5T4 tumour antigen, today’s collaboration with ImaginAb further emphasises the importance of 5T4 as a target for novel anti-cancer interventions. As a companion diagnostic, targeted molecular imaging has the potential to form the basis of sophisticated patient diagnosis and treatment approaches that can positively impact the economics of therapeutic development.”

Commenting on the collaboration, Dr Christian Behrenbruch, Chief Executive Officer of ImaginAb, said: “The 5T4 tumour antigen is an extremely promising diagnostic and therapeutic target and we are interested in 5T4 for a variety of ‘in vivo’ diagnostic indications in oncology. We are particularly enthusiastic about this target for imaging ovarian cancer as the diagnosis and staging of this tragic disease is still inadequately managed with existing clinical imaging techniques and represents a major unmet medical need.”

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Oxford BioMedica plc:

Media Enquiries:

Notes to editors

1. Oxford BioMedica®
Oxford BioMedica plc (LSE: OXB) is a biopharmaceutical company developing innovative gene-based medicines and therapeutic vaccines that aim to improve the lives of patients with high unmet medical needs. The Company’s technology platform includes a highly efficient LentiVector® gene delivery system, which has specific advantages for targeting diseases of the central nervous system and the eye; and a unique tumour antigen (5T4), which is an ideal target for anti-cancer therapy. Through in-house and collaborative research, Oxford BioMedica has a broad pipeline and its partners include Sanofi, Sigma-Aldrich and Pfizer. Further information is available at www.oxfordbiomedica.co.uk.

2. ImaginAb, Inc.
Founded in 2007 by UCLA Faculty (Drs. Robert Reiter, Anna Wu and Christian Behrenbruch), ImaginAb, Inc. is a biotechnology company specialising in the development of engineered antibody fragments for diagnostic imaging and novel therapeutic applications. The company has a significant pipeline of clinical products in development oriented towards unmet needs in cancer and immunology. ImaginAb is also developing a range of pre-clinical (animal imaging) reagents for use with microPET, microSPECT and optical imaging systems, and partners on a selective basis with biopharmaceutical companies with an interest in developing companion imaging agents for therapeutic antibody products. For more information about ImaginAb, visit www.imaginab.com.

3. 5T4 Tumour Antigen
The 5T4 tumour antigen is a unique protein found on most common types of solid cancer. It is potentially a valuable target for novel anti-cancer interventions given its restricted expression in normal tissues and its high prevalence on the surface of both primary and metastatic cancerous cells. The 5T4 tumour antigen was identified through research into the similarities between the development of the placenta during pregnancy and the progression of cancer. 5T4 is produced by both cancerous cells and also by placental and foetal cells, suggesting that the process of immunological escape in pregnancy and cancer is based on similar mechanisms. TroVax® is Oxford BioMedica’s 5T4-specific therapeutic vaccine candidate which is in Phase II development. In collaboration with Pfizer, pre-clinical evaluation of Oxford BioMedica’s 5T4-targeted antibody therapy is on-going to optimise the product for clinical development.

Los Angeles, June 5 2011 — ImaginAb, Inc. has been invited to join KeyMarker, a leading consortium of Belgian academic scientists and biotech companies for the discovery of new diagnostic and therapeutic targets for diabetes. This consortium is established under the framework of Biowin, the Health Competitiveness Cluster of the Walloon Region from Belgium. It is coordinated by IBA Molecular with Eurogentec and TraSis as industrial partners. Based on new biomarkers discovered at Université Libre de Bruxelles (ULB), its mission is to develop new targets to monitor and modulate beta cell depletion in adult-onset diabetes*. Several lead candidates will be developed in the second phase of funding of the KeyMarker consortium, to which ImaginAb will be a partner.

“Imaging beta cell depletion is a major unmet need, both in the clinic and in the development of new therapeutic modalities” said Dr. Christian Behrenbruch, Founder and CEO of ImaginAb. “ImaginAb’s role in the consortium will be to engineer several promising antibodies against novel cell surface targets into highly sensitive and selective imaging agents that have the potential to be used to image and monitor beta cell populations in critical patient subsets.”

About ImaginAb

Founded in 2007 by UCLA Faculty (Drs. Robert Reiter, Anna Wu and Christian Behrenbruch), ImaginAb, Inc. is a biotechnology company specializing in the development of engineered antibody fragments for diagnostic imaging and novel therapeutic applications. The company has a significant pipeline of clinical products in development oriented towards unmet needs in cancer and immunology. ImaginAb is also developing a range of pre-clinical (animal imaging) reagents for use with microPET, microSPECT and optical imaging systems, and partners on a selective basis with biopharmaceutical companies with an interest in developing companion imaging agents for therapeutic antibody products. For more information about ImaginAb, visit www.imaginab.com.

About KeyMarker

Program description: KeyMarker is a consortium established under Biowin, the Health Competitiveness Cluster of the Walloon Region from Belgium. The consortium’s goal is to identify molecules that can be used as radiotracers for PET or SPECT imaging and potential quantification of the pancreatic Beta-cell mass. Such molecules may lead to novel approaches for diabetic disease management, such as patient stratification, disease follow-up and new therapeutic strategies. For more information visit www.biowin.org.

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ImaginAb:

*the technologies described in this press release have not attained regulatory approval for clinical use in Europe or the USA.

Los Angeles, USA & Little Chalfont, UK – June 5, 2011 — GE Healthcare Ltd. and ImaginAb, Inc. have executed a master research agreement around the development of new PET (Positron Emission Tomography) diagnostic imaging agents based on ImaginAb’s antibody fragment technology. The agreement is launched with an initial exclusive collaboration around a novel cardiovascular target*.

“We are very pleased to have established this collaboration with GE and particularly delighted that our first project extends ImaginAb’s reach into the rapidly growing market for new PET tracers to image high-risk cardiovascular disease,” said Dr. Christian Behrenbruch, CEO of ImaginAb. “As a development partner, GE Healthcare brings tremendous and much-valued expertise in radiochemistry process development and clinical translation.”

“With the growing importance of biologics-based therapeutics in treating cancer and inflammation and our evolving understanding that cancer and cardiovascular disease are modulated by fundamental immune processes, we view this collaboration with ImaginAb as timely”, said Marivi Mendizabal, Head of Research, GE Healthcare, Medical Diagnostics. “Our vision is that technologies, such as the ImaginAb antibody fragment platform, will enable us to rapidly develop new targeted molecular diagnostics – not just for our own clinical portfolio, but as a ‘companion’ diagnostic offering to antibody/drug conjugat pipelines for our strategic biopharma partnerships”.

About ImaginAb

Founded in 2007 by UCLA Faculty (Drs. Robert Reiter, Anna Wu and Christian Behrenbruch), ImaginAb, Inc. is a biotechnology company specializing in the development of engineered antibody fragments for diagnostic imaging and novel therapeutic applications. The company has a significant pipeline of clinical products in development oriented towards unmet needs in cancer and immunology. ImaginAb is also developing a range of pre-clinical (animal imaging) reagents for use with microPET, microSPECT and optical imaging systems, and partners on a selective basis with biopharmaceutical companies with an interest in developing companion imaging agents for therapeutic antibody products. For more information about ImaginAb, visit www.imaginab.com.

About GE Healthcare

GE Healthcare provides transformational medical technologies and services that are shaping a new age of patient care. Our expertise in medical imaging and information technologies, medical diagnostics, patient monitoring systems, performance improvement, drug discovery, and biopharmaceutical manufacturing technologies is helping clinicians around the world re-imagine new ways to predict, diagnose, inform and treat disease, so their patients can live their lives to the fullest.

GE Healthcare’s broad range of products and services enable healthcare providers to better diagnose and treat cancer, heart disease, neurological diseases, and other conditions earlier. Our vision for the future is to enable a new “early health” model of care focused on earlier diagnosis, pre-symptomatic disease detection and disease prevention.

Headquartered in the United Kingdom, GE Healthcare is a $17 billion unit of General Electric Company (NYSE: GE). Worldwide, GE Healthcare employs more than 46,000 people committed to serving healthcare professionals and their patients in more than 100 countries. For more information about GE Healthcare, visit our website at www.gehealthcare.com.

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ImaginAb:

GEHC:

*the products and services described in this press release have not attained regulatory approval for clinical use in USA or UK/EU.

See the full report here, find us on page 35.

PRESS RELEASE

LOS ANGELES, April 18, 2011 — ImaginAb, Inc. and the University of California, Los Angeles (UCLA) have concluded a technology licensing agreement relating to novel fluorine chemistry for the rapid and robust labeling of proteins, peptides and biomolecules for diagnostic imaging with Positron Emission Tomography (PET).

“We are pleased that ImaginAb has expanded its technology portfolio and recognized the cutting-edge work being developed by the Crump Institute,” said Dr. Claire Wake, Director, at the university’s Office of Intellectual Property and Industry Sponsored Research (OIP-ISR).

“UCLA is truly a world leader in technologies related to PET, from Molecular and Medical Pharmacology department chair Dr. Michael Phelps’ pioneering of the field some thirty years ago to the incredible multi-disciplinary innovation occurring there today,” said Dr. Christian Behrenbruch, CEO of ImaginAb. “This technology will become an important part of ImaginAb’s strategy to combine the readily available and low-cost supply of F-18 from existing cyclotron networks with ImaginAb’s rapid development of targeted molecular imaging agents based on antibody fragments and other small protein scaffolds.”

The licensed technology originates from the UCLA’s Crump Institute for Molecular Imaging through research sponsored by the U.S. Department of Energy. The agreement grants exclusivity to ImaginAb for antibodies and antibody fragments.

About ImaginAb

Founded in 2007 by UCLA faculty members Dr. Robert Reiter, Professor of Urology and Molecular Biology, Dr. Anna Wu, Professor, Molecular & Medical Pharmacology and then-faculty member Dr. Behrenbruch, ImaginAb, Inc. is a biotechnology company specializing in the development of engineered antibody fragments for diagnostic imaging and novel therapeutic applications. The company has a significant pipeline of clinical products in development oriented towards unmet needs in cancer and immunology. ImaginAb is also developing a range of pre-clinical (animal imaging) reagents for use with microPET, microSPECT and optical imaging systems, and partners on a selective basis with biopharmaceutical companies with an interest in developing companion imaging agents for therapeutic antibody products. For more information about ImaginAb, visit www.imaginab.com.

Contact:

ImaginAb: